Combinación de oxigenoterapia hiperbárica y esteroides orales para el tratamiento de la hipoacusia súbita neurosensorial: ¿precoz o tardía?
- Autores:Matteo Cavaliere 1, Pietro De Luca 1 , Alfonso Scarpa 1,*, Adriano Maciej Strzalkowski 1 , Massimo Ralli 2 , Matteo Calvanese 1, Luisa Savignano 1, Pasquale Viola 3 , Claudia Cassandro 4, Giuseppe Chiarella 3 and Arianna Di Stadio 5
- Fecha de publicación:October 11, 2022
- Tipo:Articulos
Abstract
Background and Objectives: Several treatments are available for sudden sensorineural hearing loss (SSNHL), but no studies have compared the different treatments based on the delay from the onset of the disease. Our study aims to compare the effect of hyperbaric oxygen therapy (HBOT), oral steroids (OS), and the combination of both therapies (HBOT + OS) for treating SSNHL.
Materials and Methods: This randomized study analyzed 171 patients with SSNHL. Patients were evaluated by pure tone audiometry test (PTA) at baseline (T0) and 20 days after treatment (T1). Three groups were available: HBOT (A), OS (B), and HBOT + OS (C). After baseline PTA, patients were randomly assigned to each group. Statistical analysis was performed by one-way ANOVA and Chi-square.
Results: Patients in the HBOT + OS and HBOT groups improved their auditory function (p < 0.05). HBOT was the best choice for treatment when started by 7 days from SSNHL onset, while HBOT + OS was preferable in case of late treatment. Profound SNHL recovered equally by HBOT and HBOT + OS (p < 0.05). Upsloping SNHL obtained better auditory results by HBOT compared to HBOT + OS (p < 0.05). Downsloping and flat SSNHL had the most improvement with HBOT + OS compared to HBOT only (p < 0.05).
Conclusions: Combination of HBOT and OS is a valid treatment for SSNHL both in case of early and late treatment. Combination of HBOT and OS was the choice with the best results in case of treatment started >14 days from symptom onset.